Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline Frontier Airlines

The cheapest airline(s) flying from Des Moines to Buffalo is Frontier Airlines.

  • Frontier Airlines Frontier Airlines
  • American Airlines American Airlines
  • United Airlines United Airlines
  • Delta Air Lines Delta Air Lines
  • Southwest Airlines Southwest Airlines
Cheapest Month October

Travel Period: October 2024 - September 2025

The cheapest month(s) to fly from Des Moines to Buffalo is October.

  • Oct 2024
  • Nov 2024
  • Dec 2024
  • Jan 2025
  • Feb 2025
  • Mar 2025
  • Apr 2025
  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
Cheapest Day of the Week Thursday

The cheapest day(s) of the week to fly from Des Moines to Buffalo is Thursday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Mon, 2 Sep, 2024

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      • 05:57 DSM
        10:45 BUF
        3Hrs, 48m 1 Stop (ORD)
      • DSMDes Moines Airport 05:57 - BUF 10:45 3h 48m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 05:57
        ORDChicago O'Hare International Airport 08:10
      • ORDChicago O'Hare International Airport 07:25
        BUFBuffalo Airport 10:45
      • 3h 48m (45m)
      • 1 Stop ORD · Chicago 45m
      • American Airlines (AA 2575)Airbus
        American Airlines (AA 2550)Boeing 737 800
      • American Airlines (AA 2575)
        • M
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        • -
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      • 05:57 DSM
        12:53 BUF
        5Hrs, 56m 1 Stop (ORD)
      • DSMDes Moines Airport 05:57 - BUF 12:53 5h 56m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 05:57
        ORDChicago O'Hare International Airport 10:25
      • ORDChicago O'Hare International Airport 07:25
        BUFBuffalo Airport 12:53
      • 5h 56m (3h)
      • 1 Stop ORD · Chicago 3h
      • American Airlines (AA 2575)Airbus
        American Airlines (AA 2550)Boeing 737 800
      • American Airlines (AA 2575)
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      • 11:46 DCA
        07:25 ORD
        6Hrs, 07m 1 Stop (BUF)
      • DCAWashington Ronald Reagan National Airport 11:46 - ORD 07:25 6h 07m 1 Stop (BUF) Buffalo
      • DCAWashington Ronald Reagan National Airport 11:46
        DSMDes Moines Airport 05:57
      • BUFBuffalo Airport 13:04
        ORDChicago O'Hare International Airport 07:25
      • 6h 07m (1h 25m)
      • 1 Stop BUF · Buffalo 1h 25m
      • American Airlines (AA 5640)Crj 700 Canadair Regional
        American Airlines (AA 2575)Airbus
      • American Airlines (AA 5640)
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      • 06:00 DSM
        13:04 BUF
        6Hrs, 04m 1 Stop (DCA)
      • DSMDes Moines Airport 06:00 - BUF 13:04 6h 04m 1 Stop (DCA) Washington
      • DSMDes Moines Airport 06:00
        DCAWashington Ronald Reagan National Airport 11:46
      • DCAWashington Ronald Reagan National Airport 09:29
        BUFBuffalo Airport 13:04
      • 6h 04m (2h 17m)
      • 1 Stop DCA · Washington 2h 17m
      • American Airlines (AA 3766)Embraer Emb 175
        American Airlines (AA 5640)Crj 700 Canadair Regional
      • American Airlines (AA 3766)
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      • 06:00 DSM
        11:25 BUF
        4Hrs, 25m 1 Stop (DCA)
      • DSMDes Moines Airport 06:00 - BUF 11:25 4h 25m 1 Stop (DCA) Washington
      • DSMDes Moines Airport 06:00
        DCAWashington Ronald Reagan National Airport 10:00
      • DCAWashington Ronald Reagan National Airport 09:29
        BUFBuffalo Airport 11:25
      • 4h 25m (31m)
      • 1 Stop DCA · Washington 31m
      • American Airlines (AA 3766)Embraer Emb 175
        American Airlines (AA 5093)Crj 700 Canadair Regional
      • American Airlines (AA 3766)
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      • 06:00 DSM
        11:14 BUF
        4Hrs, 14m 1 Stop (DCA)
      • DSMDes Moines Airport 06:00 - BUF 11:14 4h 14m 1 Stop (DCA) Washington
      • DSMDes Moines Airport 06:00
        DCAWashington Ronald Reagan National Airport 09:59
      • DCAWashington Ronald Reagan National Airport 09:29
        BUFBuffalo Airport 11:14
      • 4h 14m (30m)
      • 1 Stop DCA · Washington 30m
      • American Airlines (AA 3766)Embraer Emb 175
        American Airlines (AA 5093)Crj 700 Canadair Regional
      • American Airlines (AA 3766)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 06:30 DSM
        13:17 BUF
        5Hrs, 47m 1 Stop (ORD)
      • DSMDes Moines Airport 06:30 - BUF 13:17 5h 47m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 06:30
        ORDChicago O'Hare International Airport 10:35
      • ORDChicago O'Hare International Airport 08:05
        BUFBuffalo Airport 13:17
      • 5h 47m (2h 30m)
      • 1 Stop ORD · Chicago 2h 30m
      • United Airlines (UA 5385)Embraer 175
        United Airlines (UA 4382)Canadair Regional Jet 550
      • United Airlines (UA 5385)
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      • 06:38 DSM
        11:10 BUF
        3Hrs, 32m 1 Stop (DTW)
      • DSMDes Moines Airport 06:38 - BUF 11:10 3h 32m 1 Stop (DTW) Detroit
      • DSMDes Moines Airport 06:38
        DTWDetroit Wayne County 10:00
      • DTWDetroit Wayne County 09:30
        BUFBuffalo Airport 11:10
      • 3h 32m (30m)
      • 1 Stop DTW · Detroit 30m
      • Delta Air Lines (DL 5414)Canadair Regional
        Delta Air Lines (DL 4174)Canadair Regional
      • Delta Air Lines (DL 5414)
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      • 06:39 DSM
        12:53 BUF
        5Hrs, 14m 1 Stop (CLT)
      • DSMDes Moines Airport 06:39 - BUF 12:53 5h 14m 1 Stop (CLT) Charlotte
      • DSMDes Moines Airport 06:39
        CLTCharlotte Airport 11:03
      • CLTCharlotte Airport 09:59
        BUFBuffalo Airport 12:53
      • 5h 14m (1h 04m)
      • 1 Stop CLT · Charlotte 1h 04m
      • American Airlines (AA 2488)Airbus
        American Airlines (AA 2975)Airbus
      • American Airlines (AA 2488)
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      • 07:33 DSM
        13:45 BUF
        5Hrs, 12m 1 Stop (LGA)
      • DSMDes Moines Airport 07:33 - BUF 13:45 5h 12m 1 Stop (LGA) New York City
      • DSMDes Moines Airport 07:33
        LGANew York La Guardia Airport 12:10
      • LGANew York La Guardia Airport 11:17
        BUFBuffalo Airport 13:45
      • 5h 12m (53m)
      • 1 Stop LGA · New York City 53m
      • Delta Air Lines (DL 4908)Canadair Regional
        Delta Air Lines (DL 5677)Embraer Emb 175
      • Delta Air Lines (DL 4908)
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        • -
      • 08:00 DSM
        13:17 BUF
        4Hrs, 17m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - BUF 13:17 4h 17m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 10:35
      • ORDChicago O'Hare International Airport 09:31
        BUFBuffalo Airport 13:17
      • 4h 17m (1h 04m)
      • 1 Stop ORD · Chicago 1h 04m
      • United Airlines (UA 1363)Boeing 737 900
        United Airlines (UA 4382)Canadair Regional Jet 550
      • United Airlines (UA 1363)
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        • -
      • 08:00 DSM
        13:17 BUF
        4Hrs, 17m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - BUF 13:17 4h 17m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 10:35
      • ORDChicago O'Hare International Airport 09:31
        BUFBuffalo Airport 13:17
      • 4h 17m (1h 04m)
      • 1 Stop ORD · Chicago 1h 04m
      • United Airlines (UA 1363)Boeing 737 800
        United Airlines (UA 4382)Canadair Regional Jet 550
      • United Airlines (UA 1363)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 08:00 DSM
        13:17 BUF
        4Hrs, 17m 1 Stop (ORD)
      • DSMDes Moines Airport 08:00 - BUF 13:17 4h 17m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 08:00
        ORDChicago O'Hare International Airport 10:35
      • ORDChicago O'Hare International Airport 09:31
        BUFBuffalo Airport 13:17
      • 4h 17m (1h 04m)
      • 1 Stop ORD · Chicago 1h 04m
      • United Airlines (UA 1363)Boeing 737 Max 9 Passenger
        United Airlines (UA 4382)Canadair Regional Jet 550
      • United Airlines (UA 1363)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 09:32 DSM
        16:22 BUF
        5Hrs, 50m 1 Stop (DFW)
      • DSMDes Moines Airport 09:32 - BUF 16:22 5h 50m 1 Stop (DFW) Dallas
      • DSMDes Moines Airport 09:32
        DFWDallas/Fort Worth Intl Airport 12:21
      • DFWDallas/Fort Worth Intl Airport 11:39
        BUFBuffalo Airport 16:22
      • 5h 50m (42m)
      • 1 Stop DFW · Dallas 42m
      • American Airlines (AA 3930)Embraer Emb 175
        American Airlines (AA 1724)Boeing 737 800
      • American Airlines (AA 3930)
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      • 09:32 DSM
        16:41 BUF
        6Hrs, 09m 1 Stop (DFW)
      • DSMDes Moines Airport 09:32 - BUF 16:41 6h 09m 1 Stop (DFW) Dallas
      • DSMDes Moines Airport 09:32
        DFWDallas/Fort Worth Intl Airport 12:31
      • DFWDallas/Fort Worth Intl Airport 11:39
        BUFBuffalo Airport 16:41
      • 6h 09m (52m)
      • 1 Stop DFW · Dallas 52m
      • American Airlines (AA 3930)Embraer Emb 175
        American Airlines (AA 3621)Embraer Emb 175
      • American Airlines (AA 3930)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 10:21 DSM
        16:58 BUF
        5Hrs, 37m 1 Stop (DTW)
      • DSMDes Moines Airport 10:21 - BUF 16:58 5h 37m 1 Stop (DTW) Detroit
      • DSMDes Moines Airport 10:21
        DTWDetroit Wayne County 15:50
      • DTWDetroit Wayne County 13:08
        BUFBuffalo Airport 16:58
      • 5h 37m (2h 42m)
      • 1 Stop DTW · Detroit 2h 42m
      • Delta Air Lines (DL 5058)Canadair Regional
        Delta Air Lines (DL 1292)Airbus
      • Delta Air Lines (DL 5058)
        • -
        • -
        • -
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        • -
        • -
        • -
      • 10:21 DSM
        16:58 BUF
        5Hrs, 37m 1 Stop (DTW)
      • DSMDes Moines Airport 10:21 - BUF 16:58 5h 37m 1 Stop (DTW) Detroit
      • DSMDes Moines Airport 10:21
        DTWDetroit Wayne County 15:50
      • DTWDetroit Wayne County 13:08
        BUFBuffalo Airport 16:58
      • 5h 37m (2h 42m)
      • 1 Stop DTW · Detroit 2h 42m
      • Delta Air Lines (DL 5058)Canadair Regional
        Delta Air Lines (DL 1292)Boeing 717
      • Delta Air Lines (DL 5058)
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      • 10:21 DSM
        17:01 BUF
        5Hrs, 40m 1 Stop (DTW)
      • DSMDes Moines Airport 10:21 - BUF 17:01 5h 40m 1 Stop (DTW) Detroit
      • DSMDes Moines Airport 10:21
        DTWDetroit Wayne County 15:50
      • DTWDetroit Wayne County 13:08
        BUFBuffalo Airport 17:01
      • 5h 40m (2h 42m)
      • 1 Stop DTW · Detroit 2h 42m
      • Delta Air Lines (DL 4967)Canadair Regional
        Delta Air Lines (DL 3663)Canadair Regional
      • Delta Air Lines (DL 4967)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 11:17 DSM
        17:11 BUF
        4Hrs, 54m 1 Stop (ATL)
      • DSMDes Moines Airport 11:17 - BUF 17:11 4h 54m 1 Stop (ATL) Atlanta
      • DSMDes Moines Airport 11:17
        ATLAtlanta Hartsfield-Jackson Intl Airport 15:10
      • ATLAtlanta Hartsfield-Jackson Intl Airport 14:24
        BUFBuffalo Airport 17:11
      • 4h 54m (46m)
      • 1 Stop ATL · Atlanta 46m
      • Delta Air Lines (DL 1704)Boeing 717
        Delta Air Lines (DL 2050)Airbus
      • Delta Air Lines (DL 1704)
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      • 11:30 DSM
        16:58 BUF
        4Hrs, 28m 1 Stop (ORD)
      • DSMDes Moines Airport 11:30 - BUF 16:58 4h 28m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 11:30
        ORDChicago O'Hare International Airport 14:20
      • ORDChicago O'Hare International Airport 13:02
        BUFBuffalo Airport 16:58
      • 4h 28m (1h 18m)
      • 1 Stop ORD · Chicago 1h 18m
      • United Airlines (UA 2306)Airbus
        United Airlines (UA 1448)Boeing 737 Max 8 Passenger
      • United Airlines (UA 2306)
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        • -
      • 11:36 DSM
        17:02 BUF
        4Hrs, 26m 1 Stop (ORD)
      • DSMDes Moines Airport 11:36 - BUF 17:02 4h 26m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 11:36
        ORDChicago O'Hare International Airport 14:20
      • ORDChicago O'Hare International Airport 13:08
        BUFBuffalo Airport 17:02
      • 4h 26m (1h 12m)
      • 1 Stop ORD · Chicago 1h 12m
      • United Airlines (UA 2306)Boeing 737 700
        United Airlines (UA 5609)Embraer 175
      • United Airlines (UA 2306)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 11:43 DSM
        16:58 BUF
        4Hrs, 15m 1 Stop (ORD)
      • DSMDes Moines Airport 11:43 - BUF 16:58 4h 15m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 11:43
        ORDChicago O'Hare International Airport 14:20
      • ORDChicago O'Hare International Airport 13:15
        BUFBuffalo Airport 16:58
      • 4h 15m (1h 05m)
      • 1 Stop ORD · Chicago 1h 05m
      • United Airlines (UA 2306)Boeing 737 800
        United Airlines (UA 1448)Boeing 737 Max 8 Passenger
      • United Airlines (UA 2306)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 11:55 DSM
        18:23 BUF
        5Hrs, 28m 1 Stop (MSP)
      • DSMDes Moines Airport 11:55 - BUF 18:23 5h 28m 1 Stop (MSP) Minneapolis
      • DSMDes Moines Airport 11:55
        MSPMinneapolis International Airport 15:20
      • MSPMinneapolis International Airport 13:10
        BUFBuffalo Airport 18:23
      • 5h 28m (2h 10m)
      • 1 Stop MSP · Minneapolis 2h 10m
      • Delta Air Lines (DL 4998)Canadair Regional
        Delta Air Lines (DL 1286)Airbus
      • Delta Air Lines (DL 4998)
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        • F
        • -
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      • 12:25 DSM
        19:52 BUF
        6Hrs, 27m 1 Stop (LGA)
      • DSMDes Moines Airport 12:25 - BUF 19:52 6h 27m 1 Stop (LGA) New York City
      • DSMDes Moines Airport 12:25
        LGANew York La Guardia Airport 18:20
      • LGANew York La Guardia Airport 16:09
        BUFBuffalo Airport 19:52
      • 6h 27m (2h 11m)
      • 1 Stop LGA · New York City 2h 11m
      • Delta Air Lines (DL 4915)Canadair Regional
        Delta Air Lines (DL 5196)Canadair Regional
      • Delta Air Lines (DL 4915)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 14:35 DSM
        21:15 BUF
        5Hrs, 40m 1 Stop (DEN)
      • DSMDes Moines Airport 14:35 - BUF 21:15 5h 40m 1 Stop (DEN) Denver
      • DSMDes Moines Airport 14:35
        DENDenver Intl Airport 16:10
      • DENDenver Intl Airport 15:25
        BUFBuffalo Airport 21:15
      • 5h 40m (45m)
      • 1 Stop DEN · Denver 45m
      • Southwest Airlines (WN 2210)Boeing 737 800
        Southwest Airlines (WN 1586)Boeing 737 800
      • Southwest Airlines (WN 2210)
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        • -
        • -
        • -
        • -
      • 15:00 DSM
        20:40 BUF
        4Hrs, 40m 1 Stop (ORD)
      • DSMDes Moines Airport 15:00 - BUF 20:40 4h 40m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:00
        ORDChicago O'Hare International Airport 18:05
      • ORDChicago O'Hare International Airport 16:35
        BUFBuffalo Airport 20:40
      • 4h 40m (1h 30m)
      • 1 Stop ORD · Chicago 1h 30m
      • American Airlines (AA 5889)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2050)Boeing 737 800
      • American Airlines (AA 5889)
        • -
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        • W
        • -
        • -
        • S
        • -
      • 15:19 DSM
        20:49 BUF
        4Hrs, 30m 1 Stop (ORD)
      • DSMDes Moines Airport 15:19 - BUF 20:49 4h 30m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:19
        ORDChicago O'Hare International Airport 18:08
      • ORDChicago O'Hare International Airport 16:50
        BUFBuffalo Airport 20:49
      • 4h 30m (1h 18m)
      • 1 Stop ORD · Chicago 1h 18m
      • United Airlines (UA 1568)Boeing 737 800
        United Airlines (UA 1335)Boeing 737 800
      • United Airlines (UA 1568)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 15:19 DSM
        20:49 BUF
        4Hrs, 30m 1 Stop (ORD)
      • DSMDes Moines Airport 15:19 - BUF 20:49 4h 30m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:19
        ORDChicago O'Hare International Airport 18:08
      • ORDChicago O'Hare International Airport 16:50
        BUFBuffalo Airport 20:49
      • 4h 30m (1h 18m)
      • 1 Stop ORD · Chicago 1h 18m
      • United Airlines (UA 1568)Boeing 737 900
        United Airlines (UA 1335)Boeing 737 800
      • United Airlines (UA 1568)
        • -
        • -
        • -
        • -
        • F
        • -
        • -
      • 15:19 DSM
        20:49 BUF
        4Hrs, 30m 1 Stop (ORD)
      • DSMDes Moines Airport 15:19 - BUF 20:49 4h 30m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:19
        ORDChicago O'Hare International Airport 18:08
      • ORDChicago O'Hare International Airport 16:54
        BUFBuffalo Airport 20:49
      • 4h 30m (1h 14m)
      • 1 Stop ORD · Chicago 1h 14m
      • United Airlines (UA 3671)Embraer 175
        United Airlines (UA 1335)Boeing 737 800
      • United Airlines (UA 3671)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 15:19 DSM
        20:49 BUF
        4Hrs, 30m 1 Stop (ORD)
      • DSMDes Moines Airport 15:19 - BUF 20:49 4h 30m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:19
        ORDChicago O'Hare International Airport 18:08
      • ORDChicago O'Hare International Airport 16:50
        BUFBuffalo Airport 20:49
      • 4h 30m (1h 18m)
      • 1 Stop ORD · Chicago 1h 18m
      • United Airlines (UA 1568)Boeing 737 Max 8 Passenger
        United Airlines (UA 1335)Boeing 737 800
      • United Airlines (UA 1568)
        • M
        • T
        • W
        • T
        • -
        • -
        • -
      • 15:21 DSM
        22:07 BUF
        5Hrs, 46m 1 Stop (ORD)
      • DSMDes Moines Airport 15:21 - BUF 22:07 5h 46m 1 Stop (ORD) Chicago
      • DSMDes Moines Airport 15:21
        ORDChicago O'Hare International Airport 19:26
      • ORDChicago O'Hare International Airport 16:56
        BUFBuffalo Airport 22:07
      • 5h 46m (2h 30m)
      • 1 Stop ORD · Chicago 2h 30m
      • American Airlines (AA 5889)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2050)Boeing 737 800
      • American Airlines (AA 5889)
        • M
        • -
        • -
        • T
        • F
        • -
        • S
      • 15:45 DSM
        23:44 BUF
        6Hrs, 59m 1 Stop (DCA)
      • DSMDes Moines Airport 15:45 - BUF 23:44 6h 59m 1 Stop (DCA) Washington
      • DSMDes Moines Airport 15:45
        DCAWashington Ronald Reagan National Airport 22:27
      • DCAWashington Ronald Reagan National Airport 19:15
        BUFBuffalo Airport 23:44
      • 6h 59m (3h 12m)
      • 1 Stop DCA · Washington 3h 12m
      • American Airlines (AA 5388)Crj 700 Canadair Regional
        American Airlines (AA 5241)Crj 700 Canadair Regional
      • American Airlines (AA 5388)
        • M
        • T
        • W
        • T
        • F
        • -
        • S
      • 15:45 DSM
        21:45 BUF
        5Hrs, 00m 1 Stop (DCA)
      • DSMDes Moines Airport 15:45 - BUF 21:45 5h 1 Stop (DCA) Washington
      • DSMDes Moines Airport 15:45
        DCAWashington Ronald Reagan National Airport 20:20
      • DCAWashington Ronald Reagan National Airport 19:15
        BUFBuffalo Airport 21:45
      • 5h (1h 05m)
      • 1 Stop DCA · Washington 1h 05m
      • American Airlines (AA 5388)Crj 700 Canadair Regional
        American Airlines (AA 4344)Embraer Emb 175
      • American Airlines (AA 5388)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 16:00 DSM
        23:55 BUF
        6Hrs, 55m 1 Stop (ATL)
      • DSMDes Moines Airport 16:00 - BUF 23:55 6h 55m 1 Stop (ATL) Atlanta
      • DSMDes Moines Airport 16:00
        ATLAtlanta Hartsfield-Jackson Intl Airport 21:56
      • ATLAtlanta Hartsfield-Jackson Intl Airport 19:10
        BUFBuffalo Airport 23:55
      • 6h 55m (2h 46m)
      • 1 Stop ATL · Atlanta 2h 46m
      • Delta Air Lines (DL 2155)Boeing 717
        Delta Air Lines (DL 2334)Airbus
      • Delta Air Lines (DL 2155)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 16:10 DSM
        22:33 BUF
        5Hrs, 23m 1 Stop (CLT)
      • DSMDes Moines Airport 16:10 - BUF 22:33 5h 23m 1 Stop (CLT) Charlotte
      • DSMDes Moines Airport 16:10
        CLTCharlotte Airport 20:45
      • CLTCharlotte Airport 19:29
        BUFBuffalo Airport 22:33
      • 5h 23m (1h 16m)
      • 1 Stop CLT · Charlotte 1h 16m
      • American Airlines (AA 2962)Airbus
        American Airlines (AA 703)Airbus
      • American Airlines (AA 2962)
        • -
        • T
        • W
        • -
        • -
        • -
        • -
      • 16:10 DSM
        22:33 BUF
        5Hrs, 23m 1 Stop (CLT)
      • DSMDes Moines Airport 16:10 - BUF 22:33 5h 23m 1 Stop (CLT) Charlotte
      • DSMDes Moines Airport 16:10
        CLTCharlotte Airport 20:45
      • CLTCharlotte Airport 19:29
        BUFBuffalo Airport 22:33
      • 5h 23m (1h 16m)
      • 1 Stop CLT · Charlotte 1h 16m
      • American Airlines (AA 2962)Airbus
        American Airlines (AA 703)Airbus
      • American Airlines (AA 2962)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 16:51 DSM
        00:44 BUF
        6Hrs, 53m 1 Stop (CLT)
      • DSMDes Moines Airport 16:51 - BUF 00:44 6h 53m 1 Stop (CLT) Charlotte
      • DSMDes Moines Airport 16:51
        CLTCharlotte Airport 22:55
      • CLTCharlotte Airport 20:10
        BUFBuffalo Airport 00:44
      • 6h 53m (2h 45m)
      • 1 Stop CLT · Charlotte 2h 45m
      • American Airlines (AA 2962)Airbus
        American Airlines (AA 180)Airbus
      • American Airlines (AA 2962)
        • M
        • -
        • -
        • T
        • F
        • -
        • S
      • 17:25 DSM
        23:55 BUF
        5Hrs, 30m 1 Stop (DTW)
      • DSMDes Moines Airport 17:25 - BUF 23:55 5h 30m 1 Stop (DTW) Detroit
      • DSMDes Moines Airport 17:25
        DTWDetroit Wayne County 22:50
      • DTWDetroit Wayne County 20:19
        BUFBuffalo Airport 23:55
      • 5h 30m (2h 31m)
      • 1 Stop DTW · Detroit 2h 31m
      • Delta Air Lines (DL 5035)Canadair Regional
        Delta Air Lines (DL 2220)Airbus
      • Delta Air Lines (DL 5035)
        • M
        • T
        • W
        • T
        • F
        • -
        • S
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      How far is Buffalo from Des Moines?

      The flight distance between Des Moines and Buffalo is 1219km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 05:57. The last flight of the day departs at 11:46. See the full list of flight times on Wego.

      All Airports in Des Moines

      Des Moines Airport DSM

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      Buffalo Airport BUF

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